Curriculum Vitae
Prof. André M. GOFFINET, MD, PhD
Place and date of birth : Sainte-Cécile (Belgium), 21 November 1950
Address : Rue Dohet, 14
B5000 Namur
National Reg. : 50.11.21-179.27
Cell phone: +32 – (0) 473 899818
Email : angoffinet@gmail.com
Education :
1975: Medical Degree (summa cum laude) U. Louvain (Belgium)
1979: Belgian board in Neurology
1984: PhD Thesis "Agrégation de l'enseignement supérieur", U. Louvain
Positions:
1975 – 78: clinical training (resident) in Neurology. U. Louvain
1978 – 83: National Fund for Scientific Research (FNRS), Developmental Neurology, U. Louvain
1982 – 83: NIH Fogarty Fellowship, Harvard Med. Sch. & Mass. Gen. Hospital, Boston.
1983: Tenured research position FNRS (“Chercheur qualifié”), U. Louvain.
1984 – 89: Head of the Positron Tomography Laboratory, U. Louvain.
1987: "Maître de Recherche" FNRS, U. Louvain.
1989 – 2001: Full Professor, Human Physiology & Physiopathology. U. Namur, Belgium
2001 – 2016: Full Professor. Dev. Neurobiol, U. Louvain Medical School, Brussels
2016- present: Professor Emeritus, University of Louvain
Scientific indexes/metrics Google Scholar : https://scholar.google.be/citations?user=RK6oLykAAAAJ&hl=en
Oct ’21: H-index 64, citations 13186
Publications (pubmed, Oct ‘21) 139
Biosketch :
After my MD (U. Louvain, 1975), I trained in Clinical Neurology (board in 1979), and went on to do a PhD in
Developmental Neurobiology, mostly working on reeler mutant mice (1978-82). I then worked as a postdoc at
Harvard/MGH for one year before coming back at U. Louvain to start and direct the Positron Tomography (PET)
functional imaging laboratory that was just installed at cyclotron center at Louvain-la-Neuve (1984-1989). In
1989, I moved to the U. Namur to resume my work in development, and I cloned the reelin gene in 1995. I came
back to U. Louvain in 2001, where I discovered a previously unrecognized key axon guidance system
implicating Celsr3 and Fzd3, which has been my main intellectual interest ever since.
Expertise and original contributions:
Human brain development (ref 3).
Evolution of cerebral cortex organization in reptiles, birds and mammals (ref 1).
In vivo imaging of brain metabolism, with the first demonstration that synaptic revision occurs in the developing
human visual cortex (ref 2).
Neurogenetics, with positional cloning of the reeler gene encoding reelin (ref 4).
Production of monoclonal antibodies to reelin (G10 & 142, used all over the world) (ref 5).
Biochemistry of signalling pathways (ref 7).
Axon guidance and regeneration: Celsr3 and Fzd3 as a novel major pathway (refs 6, 8-10, reviewed in Tissir &
Goffinet, Nat Rev Neurosci 2013, 14:525-35).
Ten selected original publications (not necessarily the most cited, reviews excluded)
1. Goffinet AM (1983) The embryonic development of the cortical plate in reptiles: a comparative study in Emys
orbicularis and Lacerta agilis. Journal of Comparative Neurology 215:437-452.
And the following review:
Goffinet AM. The evolution of cortical development: the synapsid-diapsid divergence. Development. 2017 Nov
15;144(22):4061-4077
2. Veraart C, De Volder AG, Wanet-Defalque MC, Bol A, Michel C, Goffinet AM (1990) Glucose utilization in
human visual cortex is abnormally elevated in blindness of early onset but decreased in blindness of late onset.
Brain Research 510:115-121.
3. Gadisseux JF, Goffinet AM, Lyon G, Evrard P (1992) The human transient subpial granular layer: an optical,
immunohistochemical, and ultrastructural analysis. Journal of Comparative Neurology 324:94-114.
4. Bar I, Lambert De Rouvroit C, Royaux I, Krizman DB, Dernoncourt C, Ruelle D, Beckers MC, Goffinet AM
(1995) A YAC contig containing the reeler locus with preliminary characterization of candidate gene fragments.
Genomics 26:543-549.
5. de Bergeyck V, Naerhuyzen B, Goffinet AM, Lambert de Rouvroit C (1998) A panel of monoclonal
antibodies against reelin, the extracellular matrix protein defective in reeler mutant mice. Journal of
Neuroscience Methods 82:17-24.
6. Tissir F, Bar I, Jossin Y, De Backer O, Goffinet AM (2005) Protocadherin Celsr3 is crucial in axonal tract
development. Nature Neuroscience 8:451-457.
7. Jossin Y, Gui L, Goffinet AM (2007) Processing of Reelin by embryonic neurons is important for function in
tissue but not in dissociated cultured neurons. Journal of Neuroscience 27:4243-4252.
8. Zhou L, Bar I, Achouri Y, Campbell K, De Backer O, Hebert JM, Jones K, Kessaris N, de Rouvroit CL,
O'Leary D, Richardson WD, Goffinet AM, Tissir F (2008) Early forebrain wiring: genetic dissection using
conditional Celsr3 mutant mice. Science 320:946-949.
9. Tissir F, Qu Y, Montcouquiol M, Zhou L, Komatsu K, Shi D, Fujimori T, Labeau J, Tyteca D, Courtoy P,
Poumay Y, Uemura T, Goffinet AM (2010) Lack of cadherins Celsr2 and Celsr3 impairs ependymal
ciliogenesis, leading to fatal hydrocephalus. Nature Neuroscience 13:700-707.
10. Wang W, Jossin Y, Chai G, Lien WH, Tissir F, Goffinet AM. Feedback regulation of apical progenitor fate
by immature neurons through Wnt7-Celsr3-Fzd3 signalling. Nat Commun. 2016;7:10936. doi:
10.1038/ncomms10936.
Teaching experience
Neuroanatomy , bachelor medical students (16 years)
Human Physiology (nervous system, kidney, cardiovascular, respiration, internal milieu, reproduction) bachelor
medical students (13 years)
Human Embryology, bachelor medical and biomed students (11 years)
Grants and honors
Present grants:
IAP networks coordinator, (ending October 2017) Wiring the Brain (WiBrain), 180.000 EURO/year
Projet de Recherche Belgian Fonds National de la Recherche Scientifique (end oct 2017) 40.000 Euro/year
WELBIO (Excellence wallonia region, Belgium) (end oct 2017) 150.000 Euro/year
Honors:
Hoechst Prize, 1984
Past president, Belgian society for Neuroscience
Past president, Belgian Soc Cell and Dev Biol
Past president and founder of the Institute of Neuroscience at Univ. Louvain
Full publication list (pubmed refs, no abstracts, no local journals)
Qin J, Wang M, Zhao T, Xiao X, Li X, Yang J, Yi L, Goffinet AM, Qu Y, Zhou L. Early Forebrain Neurons and
Scaffold Fibers in Human Embryos. Cereb Cortex. 2020 Mar 14;30(3):913-928. doi: 10.1093/cercor/bhz136.
Goffinet AM. The evolution of cortical development: the synapsid-diapsid divergence. Development. 2017 Nov
15;144(22):4061-4077. doi: 10.1242/dev.153908.
Goffinet AM, Tissir F. Atypical Cadherins CELSR1-3. Sem Cell and Dev. Biol., 2017, Sep;69:102-110. doi:
10.1016/j.semcdb.2017.07.014. Epub 2017 Jul 15.
Boucherie C, Boutin C, Jossin Y, Schakman O, Goffinet AM, Ris L, Gailly P, Tissir F. Neural progenitor fate
decision defects, cortical hypoplasia and behavioral impairment in Celsr1-deficient mice. Mol Psychiatry. 2018
Mar;23(3):723-734. doi: 10.1038/mp.2017.236. Epub 2017 Dec 19.
Damiani D, Goffinet AM, Alberts A, Tissir F. Lack of Diaph3 relaxes the spindle checkpoint causing the loss of
neural progenitors. Nat Commun. 2016 Nov 16;7:13509. doi: 10.1038/ncomms13509.
Wang Y, Williams J, Rattner A, Wu S, Bassuk AG, Goffinet AM, Nathans J. Patterning of papillae on the mouse
tongue: A system for the quantitative assessment of planar cell polarity signaling. Dev Biol. 2016. pii: S0012-
1606(16)30439-0. doi: 10.1016/j.ydbio.2016.09.004.
Glasco DM, Pike W, Qu Y, Reustle L, Misra K, Di Bonito M, Studer M, Fritzsch B, Goffinet AM, Tissir F,
Chandrasekhar A. The atypical cadherin Celsr1 functions non-cell autonomously to block rostral migration of
facial branchiomotor neurons in mice. Dev Biol. 2016; 417(1):40-9. doi: 10.1016/j.ydbio.2016.07.004.
Feng J, Xian Q, Guan T, Hu J, Wang M, Huang Y, So KF, Evans SM, Chai G, Goffinet AM, Qu Y, Zhou L.
Celsr3 and Fzd3 Organize a Pioneer Neuron Scaffold to Steer Growing Thalamocortical Axons. Cereb Cortex.
2016, 26: 3323-34. doi: 10.1093/cercor/bhw132.
Shen N, Qu Y, Yu Y, So KF, Goffinet AM, Vardi N, Xu Y, Zhou L. Frizzled3 Shapes the Development of
Retinal Rod Bipolar Cells. Invest Ophthalmol Vis Sci. 2016; 57:2788-96. doi: 10.1167/iovs.16-19281.
Wang W, Jossin Y, Chai G, Lien WH, Tissir F, Goffinet AM. Feedback regulation of apical progenitor fate by
immature neurons through Wnt7-Celsr3-Fzd3 signalling. Nat Commun. 2016;7:10936. doi:
10.1038/ncomms10936.
Chai G, Goffinet AM, Tissir F. Celsr3 and Fzd3 in axon guidance. Int J Biochem Cell Biol. 2015 Jul;64:11-4.
doi: 10.1016/j.biocel.2015.03.013. Epub 2015 Mar 23.PubMed PMID: 25813877.
Liebscher I, Ackley B, Araç D, Ariestanti DM, Aust G, Bae BI, Bista BR,Bridges JP, Duman JG, Engel FB,
Giera S, Goffinet AM, Hall RA, Hamann J, HartmannN, Lin HH, Liu M, Luo R, Mogha A, Monk KR, Peeters
MC, Prömel S, Ressl S, Schiath HB, Sigoillot SM, Song H, Talbot WS, Tall GG, White JP, Wolfrum U, Xu L,
Piao X. New functions and signaling mechanisms for the class of adhesion Gprotein-coupled receptors. Ann N Y
Acad Sci. 2014 Dec;1333:43-64. doi:10.1111/nyas.12580. Epub 2014 Nov 25. PubMed PMID: 25424900;
PubMed CentralPMCID: PMC4278406.
Shi D, Komatsu K, Hirao M, Toyooka Y, Koyama H, Tissir F, Goffinet AM, Uemura T, Fujimori T. Celsr1 is
required for the generation of polarity at multiplelevels of the mouse oviduct. Development. 2014
Dec;141(23):4558-68. doi:10.1242/dev.115659. Epub 2014 Nov 18. PubMed PMID: 25406397.
Chai G, Zhou L, Manto M, Helmbacher F, Clotman F, Goffinet AM, Tissir F.Celsr3 is required in motor neurons
to steer their axons in the hindlimb. Nat Neurosci. 2014 Sep;17(9):1171-9. doi: 10.1038/nn.3784. Epub 2014
Aug 10. PubMed PMID: 25108913.
Boutin C, Labedan P, Dimidschstein J, Richard F, Cremer H, André P, Yang Y, Montcouquiol M, Goffinet
AM, Tissir F. A dual role for planar cell polarity genesin ciliated cells. Proc Natl Acad Sci U S A. 2014 Jul
29;111(30):E3129-38. doi: 10.1073/pnas.1404988111. Epub 2014 Jul 14. PubMed PMID: 25024228; PubMed
Central PMCID: PMC4121795.
Qu Y, Huang Y, Feng J, Alvarez-Bolado G, Grove EA, Yang Y, Tissir F, Zhou L,Goffinet AM. Genetic
evidence that Celsr3 and Celsr2, together with Fzd3, regulate forebrain wiring in a Vangl-independent manner.
Proc Natl Acad Sci U SA. 2014 Jul 22;111(29):E2996-3004. doi: 10.1073/pnas.1402105111. Epub 2014 Jul 7.
PubMed PMID: 25002511; PubMed Central PMCID: PMC4115502.
Onishi K, Shafer B, Lo C, Tissir F, Goffinet AM, Zou Y. Antagonistic functions of Dishevelleds regulate
Frizzled3 endocytosis via filopodia tips in Wnt-mediated growth cone guidance. J Neurosci. 2013 Dec
4;33(49):19071-85. doi:10.1523/JNEUROSCI.2800-13.2013. PubMed PMID: 24305805; PubMed Central
PMCID: PMC3850035.
Tissir F, Goffinet AM. Shaping the nervous system: role of the core planar
cell polarity genes. Nat Rev Neurosci. 2013 Aug;14(8):525-35. doi:
10.1038/nrn3525. Epub 2013 Jul 10. Review. PubMed PMID: 23839596.
Tissir F, Goffinet AM. Atypical cadherins Celsr1-3 and planar cell polarity in
vertebrates. Prog Mol Biol Transl Sci. 2013;116:193-214. doi:
10.1016/B978-0-12-394311-8.00009-1. Review. PubMed PMID: 23481196.
Sasselli V, Boesmans W, Vanden Berghe P, Tissir F, Goffinet AM, Pachnis V.
Planar cell polarity genes control the connectivity of enteric neurons. J Clin
Invest. 2013 Apr;123(4):1763-72. doi: 10.1172/JCI66759. Epub 2013 Mar 8. PubMed
PMID: 23478408; PubMed Central PMCID: PMC3613929.
Vardarajan B, Vergote D, Tissir F, Logue M, Yang J, Daude N, Ando K, Rogaeva
E, Lee J, Cheng R, Brion JP, Ghani M, Shi B, Baldwin CT, Kar S, Mayeux R, Fraser
P, Goffinet AM, George-Hyslop PS, Farrer LA, Westaway D. Role of p73 in Alzheimer
disease: lack of association in mouse models or in human cohorts. Mol
Neurodegener. 2013 Feb 15;8:10. doi: 10.1186/1750-1326-8-10. PubMed PMID:
23414597; PubMed Central PMCID: PMC3614544.
Boutin C, Goffinet AM, Tissir F. Celsr1-3 cadherins in PCP and brain
development. Curr Top Dev Biol. 2012;101:161-83. doi:
10.1016/B978-0-12-394592-1.00010-7. Review. PubMed PMID: 23140629.
Tissir F, Goffinet AM. Cilia: conductors' batons of neuronal maturation. Nat
Neurosci. 2012 Feb 24;15(3):344-5. doi: 10.1038/nn.3050. PubMed PMID: 22362103.
Oeschger FM, Wang WZ, Lee S, GarcÃa-Moreno F, Goffinet AM, Arbonés ML, Rakic
S, Molnár Z. Gene expression analysis of the embryonic subplate. Cereb Cortex.
2012 Jun;22(6):1343-59. doi: 10.1093/cercor/bhr197. Epub 2011 Aug 22. PubMed
PMID: 21862448.
Tissir F, Goffinet AM. p73 and p63: Estranged relatives? Cell Cycle. 2011 May
1;10(9):1351. Epub 2011 May 1. PubMed PMID: 21460637.
Qu Y, Glasco DM, Zhou L, Sawant A, Ravni A, Fritzsch B, Damrau C, Murdoch JN,
Evans S, Pfaff SL, Formstone C, Goffinet AM, Chandrasekhar A, Tissir F. Atypical
cadherins Celsr1-3 differentially regulate migration of facial branchiomotor
neurons in mice. J Neurosci. 2010 Jul 14;30(28):9392-401. doi:
10.1523/JNEUROSCI.0124-10.2010. PubMed PMID: 20631168; PubMed Central PMCID:
PMC3069688.
Tissir F, Goffinet AM. Planar cell polarity signaling in neural development.
Curr Opin Neurobiol. 2010 Oct;20(5):572-7. doi: 10.1016/j.conb.2010.05.006. Epub
2010 Jun 14. Review. PubMed PMID: 20554443.
Zhou L, Gall D, Qu Y, Prigogine C, Cheron G, Tissir F, Schiffmann SN,
Goffinet AM. Maturation of "neocortex isole" in vivo in mice. J Neurosci. 2010
Jun 9;30(23):7928-39. doi: 10.1523/JNEUROSCI.6005-09.2010. PubMed PMID: 20534841.
Tissir F, Qu Y, Montcouquiol M, Zhou L, Komatsu K, Shi D, Fujimori T, Labeau
J, Tyteca D, Courtoy P, Poumay Y, Uemura T, Goffinet AM. Lack of cadherins Celsr2
and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus. Nat
Neurosci. 2010 Jun;13(6):700-7. doi: 10.1038/nn.2555. Epub 2010 May 16. PubMed
PMID: 20473291.
Ravni A, Tissir F, Goffinet AM. DeltaNp73 transcription factors modulate cell
survival and tumor development. Cell Cycle. 2010 Apr 15;9(8):1523-7. Epub 2010
Apr 15. PubMed PMID: 20372082.
Tissir F, Ravni A, Achouri Y, Riethmacher D, Meyer G, Goffinet AM. DeltaNp73
regulates neuronal survival in vivo. Proc Natl Acad Sci U S A. 2009 Sep
29;106(39):16871-6. doi: 10.1073/pnas.0903191106. Epub 2009 Sep 10. PubMed PMID:
19805388; PubMed Central PMCID: PMC2757832.
Ravni A, Qu Y, Goffinet AM, Tissir F. Planar cell polarity cadherin Celsr1
regulates skin hair patterning in the mouse. J Invest Dermatol. 2009
Oct;129(10):2507-9. doi: 10.1038/jid.2009.84. Epub 2009 Apr 9. PubMed PMID:
19357712.
Zhou L, Qu Y, Tissir F, Goffinet AM. Role of the atypical cadherin Celsr3
during development of the internal capsule. Cereb Cortex. 2009 Jul;19 Suppl
1:i114-9. doi: 10.1093/cercor/bhp032. Epub 2009 Apr 6. PubMed PMID: 19349379.
Zhou L, Goffinet AM, Tissir F. [Role of the cadherin Celsr3 in the
connectivity of the cerebral cortex]. Med Sci (Paris). 2008 Dec;24(12):1025-7.
doi: 10.1051/medsci/200824121025. French. PubMed PMID: 19116108.
Hoerder-Suabedissen A, Wang WZ, Lee S, Davies KE, Goffinet AM, Rakić S,
Parnavelas J, Reim K, Nicolić M, Paulsen O, Molnár Z. Novel markers reveal
subpopulations of subplate neurons in the murine cerebral cortex. Cereb Cortex.
2009 Aug;19(8):1738-50. doi: 10.1093/cercor/bhn195. Epub 2008 Nov 13. PubMed
PMID: 19008461.
Zhou L, Tissir F, Goffinet AM. The atypical cadherin Celsr3 regulates the
development of the axonal blueprint. Novartis Found Symp. 2007;288:130-4;
discussion 134-40, 276-81. Review. PubMed PMID: 18494256.
Zhou L, Bar I, Achouri Y, Campbell K, De Backer O, Hebert JM, Jones K,
Kessaris N, de Rouvroit CL, O'Leary D, Richardson WD, Goffinet AM, Tissir F.
Early forebrain wiring: genetic dissection using conditional Celsr3 mutant mice.
Science. 2008 May 16;320(5878):946-9. doi: 10.1126/science.1155244. PubMed PMID:
18487195; PubMed Central PMCID: PMC2746700.
Jossin Y, Goffinet AM. Reelin signals through phosphatidylinositol 3-kinase
and Akt to control cortical development and through mTor to regulate dendritic
growth. Mol Cell Biol. 2007 Oct;27(20):7113-24. Epub 2007 Aug 13. PubMed PMID:
17698586; PubMed Central PMCID: PMC2168915.
Jossin Y, Gui L, Goffinet AM. Processing of Reelin by embryonic neurons is
important for function in tissue but not in dissociated cultured neurons. J
Neurosci. 2007 Apr 18;27(16):4243-52. PubMed PMID: 17442808.
Goffinet AM. What makes us human? A biased view from the perspective of
comparative embryology and mouse genetics. J Biomed Discov Collab. 2006 Nov
29;1:16. PubMed PMID: 17132178; PubMed Central PMCID: PMC1769396.
Price DJ, Kennedy H, Dehay C, Zhou L, Mercier M, Jossin Y, Goffinet AM,
Tissir F, Blakey D, Molnár Z. The development of cortical connections. Eur J
Neurosci. 2006 Feb;23(4):910-20. Review. PubMed PMID: 16519656.
Forster E, Jossin Y, Zhao S, Chai X, Frotscher M, Goffinet AM. Recent
progress in understanding the role of Reelin in radial neuronal migration, with
specific emphasis on the dentate gyrus. Eur J Neurosci. 2006 Feb;23(4):901-9.
Review. PubMed PMID: 16519655.
Molnar Z, Goffinet AM. Foreword to reviews on molecular and cellular basis of
cortical development (CONCORDE). Eur J Neurosci. 2006 Feb;23(4):845-6. PubMed
PMID: 16519649.
Tissir F, Goffinet AM. Expression of planar cell polarity genes during
development of the mouse CNS. Eur J Neurosci. 2006 Feb;23(3):597-607. PubMed
PMID: 16487141.
Zhou L, Jossin Y, Goffinet AM. Identification of small molecules that
interfere with radial neuronal migration and early cortical plate development.
Cereb Cortex. 2007 Jan;17(1):211-20. Epub 2006 Feb 15. PubMed PMID: 16481563.
Tissir F, Bar I, Jossin Y, De Backer O, Goffinet AM. Protocadherin Celsr3 is
crucial in axonal tract development. Nat Neurosci. 2005 Apr;8(4):451-7. Epub 2005
Mar 20. Erratum in: Nat Neurosci. 2006 Jan;9(1):147. De Backer, Olivier [added].
PubMed PMID: 15778712.
Perez-Garcia CG, Tissir F, Goffinet AM, Meyer G. Reelin receptors in
developing laminated brain structures of mouse and human. Eur J Neurosci. 2004
Nov;20(10):2827-32. PubMed PMID: 15548227.
Kuvbachieva A, Bestel AM, Tissir F, Maloum I, Guimiot F, Ramoz N, Bourgeois
F, Moalic JM, Goffinet AM, Simonneau M. Identification of a novel brain-specific
and Reelin-regulated gene that encodes a protein colocalized with synapsin. Eur J
Neurosci. 2004 Aug;20(3):603-10. PubMed PMID: 15255972.
Tissir F, Wang CE, Goffinet AM. Expression of the chemokine receptor Cxcr4
mRNA during mouse brain development. Brain Res Dev Brain Res. 2004 Mar
22;149(1):63-71. PubMed PMID: 15013630.
Ignatova N, Sindic CJ, Goffinet AM. Characterization of the various forms of
the Reelin protein in the cerebrospinal fluid of normal subjects and in
neurological diseases. Neurobiol Dis. 2004 Mar;15(2):326-30. PubMed PMID:
15006702.
Jossin Y, Ignatova N, Hiesberger T, Herz J, Lambert de Rouvroit C, Goffinet
AM. The central fragment of Reelin, generated by proteolytic processing in vivo,
is critical to its function during cortical plate development. J Neurosci. 2004
Jan 14;24(2):514-21. PubMed PMID: 14724251.
Jossin Y, Ogawa M, Metin C, Tissir F, Goffinet AM. Inhibition of SRC family
kinases and non-classical protein kinases C induce a reeler-like malformation of
cortical plate development. J Neurosci. 2003 Oct 29;23(30):9953-9. Erratum in: J
Neurosci. 2005 Jun 29;25(26):6260. PubMed PMID: 14586026.
Bock HH, Jossin Y, Liu P, Förster E, May P, Goffinet AM, Herz J.
Phosphatidylinositol 3-kinase interacts with the adaptor protein Dab1 in response
to Reelin signaling and is required for normal cortical lamination. J Biol Chem.
2003 Oct 3;278(40):38772-9. Epub 2003 Jul 25. PubMed PMID: 12882964.
Tissir F, Goffinet AM. Reelin and brain development. Nat Rev Neurosci. 2003
Jun;4(6):496-505. Review. PubMed PMID: 12778121.
Jossin Y, Bar I, Ignatova N, Tissir F, De Rouvroit CL, Goffinet AM. The
reelin signaling pathway: some recent developments. Cereb Cortex. 2003
Jun;13(6):627-33. Review. PubMed PMID: 12764038.
Meyer G, De Rouvroit CL, Goffinet AM, Wahle P. Disabled-1 mRNA and protein
expression in developing human cortex. Eur J Neurosci. 2003 Feb;17(3):517-25.
PubMed PMID: 12581169.
Tissir F, Lambert De Rouvroit C, Sire JY, Meyer G, Goffinet AM. Reelin
expression during embryonic brain development in Crocodylus niloticus. J Comp
Neurol. 2003 Mar 10;457(3):250-62. PubMed PMID: 12541309.
Bar I, Tissir F, Lambert de Rouvroit C, De Backer O, Goffinet AM. The gene
encoding disabled-1 (DAB1), the intracellular adaptor of the Reelin pathway,
reveals unusual complexity in human and mouse. J Biol Chem. 2003 Feb
21;278(8):5802-12. Epub 2002 Nov 21. PubMed PMID: 12446734.
Tissir F, Lambert de Rouvroit C, Goffinet AM. The role of reelin in the
development and evolution of the cerebral cortex. Braz J Med Biol Res. 2002
Dec;35(12):1473-84. PubMed PMID: 12436189.
Andersen TE, Finsen B, Goffinet AM, Issinger OG, Boldyreff B. A reeler mutant
mouse with a new, spontaneous mutation in the reelin gene. Brain Res Mol Brain
Res. 2002 Sep 30;105(1-2):153-6. PubMed PMID: 12399118.
Tissir F, Bar I, Goffinet AM, Lambert De Rouvroit C. Expression of the
ankyrin repeat domain 6 gene (Ankrd6) during mouse brain development. Dev Dyn.
2002 Aug;224(4):465-9. PubMed PMID: 12203740.
Kuvbachieva AA, Goffinet AM. A modification of Representational Difference
Analysis, with application to the cloning of a candidate in the Reelin signalling
pathway. BMC Mol Biol. 2002 Apr 24;3:6. Epub 2002 Apr 24. PubMed PMID: 12022920;
PubMed Central PMCID: PMC113762.
Tissir F, De-Backer O, Goffinet AM, Lambert de Rouvroit C. Developmental
expression profiles of Celsr (Flamingo) genes in the mouse. Mech Dev. 2002
Mar;112(1-2):157-60. PubMed PMID: 11850187.
Jossin Y, Goffinet AM. Reelin does not directly influence axonal growth. J
Neurosci. 2001 Dec 1;21(23):RC183. PubMed PMID: 11717386.
Lambert de Rouvroit C, Goffinet AM. Neuronal migration. Mech Dev. 2001
Jul;105(1-2):47-56. Review. PubMed PMID: 11429281.
Hevner RF, Shi L, Justice N, Hsueh Y, Sheng M, Smiga S, Bulfone A, Goffinet
AM, Campagnoni AT, Rubenstein JL. Tbr1 regulates differentiation of the preplate
and layer 6. Neuron. 2001 Feb;29(2):353-66. PubMed PMID: 11239428.
Bar I, Lambert de Rouvroit C, Goffinet AM. The Reelin signaling pathway in
mouse cortical development. Eur J Morphol. 2000 Dec;38(5):321-5. Review. PubMed
PMID: 11151045.
Bar I, Lambert de Rouvroit C, Goffinet AM. The evolution of cortical
development. An hypothesis based on the role of the Reelin signaling pathway.
Trends Neurosci. 2000 Dec;23(12):633-8. Review. PubMed PMID: 11137154.
Bar I, Goffinet AM. Evolution of cortical lamination: the reelin/Dab1
pathway. Novartis Found Symp. 2000;228:114-25; discussion 125-8. Review. PubMed
PMID: 10929319.
Bernier B, Bar I, D'Arcangelo G, Curran T, Goffinet AM. Reelin mRNA
expression during embryonic brain development in the chick. J Comp Neurol. 2000
Jul 3;422(3):448-63. PubMed PMID: 10861519.
Bar I, Lambert de Rouvroit C, Goffinet AM. The Reelin-signaling pathway and
mouse cortical development. Results Probl Cell Differ. 2000;30:255-76. Review.
PubMed PMID: 10857193.
Walsh CA, Goffinet AM. Potential mechanisms of mutations that affect neuronal
migration in man and mouse. Curr Opin Genet Dev. 2000 Jun;10(3):270-4. Review.
PubMed PMID: 10826984.
Meyer G, Schaaps JP, Moreau L, Goffinet AM. Embryonic and early fetal
development of the human neocortex. J Neurosci. 2000 Mar 1;20(5):1858-68. PubMed
PMID: 10684887.
Meyer G, Goffinet AM, Fairén A. What is a Cajal-Retzius cell? A reassessment
of a classical cell type based on recent observations in the developing
neocortex. Cereb Cortex. 1999 Dec;9(8):765-75. PubMed PMID: 10600995.
Goffinet AM, Bar I, Bernier B, Trujillo C, Raynaud A, Meyer G. Reelin
expression during embryonic brain development in lacertilian lizards. J Comp
Neurol. 1999 Nov 29;414(4):533-50. PubMed PMID: 10531544.
Bernier B, Bar I, Pieau C, Lambert De Rouvroit C, Goffinet AM. Reelin mRNA
expression during embryonic brain development in the turtle Emys orbicularis. J
Comp Neurol. 1999 Oct 25;413(3):463-79. PubMed PMID: 10502252.
Bar I, Goffinet AM. Developmental neurobiology. Decoding the Reelin signal.
Nature. 1999 Jun 17;399(6737):645-6. PubMed PMID: 10385113.
Lambert de Rouvroit C, Bernier B, Royaux I, de Bergeyck V, Goffinet AM.
Evolutionarily conserved, alternative splicing of reelin during brain
development. Exp Neurol. 1999 Apr;156(2):229-38. PubMed PMID: 10328932.
de Bergeyck V, Naerhuyzen B, Goffinet AM, Lambert de Rouvroit C. A panel of
monoclonal antibodies against reelin, the extracellular matrix protein defective
in reeler mutant mice. J Neurosci Methods. 1998 Jul 1;82(1):17-24. PubMed PMID:
10223511.
Lambert de Rouvroit C, de Bergeyck V, Cortvrindt C, Bar I, Eeckhout Y,
Goffinet AM. Reelin, the extracellular matrix protein deficient in reeler mutant
mice, is processed by a metalloproteinase. Exp Neurol. 1999 Mar;156(1):214-7.
PubMed PMID: 10192793.
Lambert de Rouvroit C, Goffinet AM. A new view of early cortical development.
Biochem Pharmacol. 1998 Dec 1;56(11):1403-9. Review. PubMed PMID: 9827572.
Lambert de Rouvroit C, Goffinet AM. The reeler mouse as a model of brain
development. Adv Anat Embryol Cell Biol. 1998;150:1-106. Review. PubMed PMID:
9816727.
Royaux I, Minner F, Goffinet AM, de Rouvroit CL. A DnaJ-like gene, Hsj2, maps
to mouse chromosome 5, at approximately 24 cM from the centromere. Genomics. 1998
Nov 1;53(3):415. PubMed PMID: 9799614.
Lambert de Rouvroit C, Goffinet AM. Cloning of human DAB1 and mapping to
chromosome 1p31-p32. Genomics. 1998 Oct 15;53(2):246-7. PubMed PMID: 9790777.
Gilmore EC, Ohshima T, Goffinet AM, Kulkarni AB, Herrup K. Cyclin-dependent
kinase 5-deficient mice demonstrate novel developmental arrest in cerebral
cortex. J Neurosci. 1998 Aug 15;18(16):6370-7. PubMed PMID: 9698328.
Meyer G, Goffinet AM. Prenatal development of reelin-immunoreactive neurons
in the human neocortex. J Comp Neurol. 1998 Jul 20;397(1):29-40. PubMed PMID:
9671277.
Molnar Z, Adams R, Goffinet AM, Blakemore C. The role of the first
postmitotic cortical cells in the development of thalamocortical innervation in
the reeler mouse. J Neurosci. 1998 Aug 1;18(15):5746-65. PubMed PMID: 9671664.
Royaux I, Lambert de Rouvroit C, D'Arcangelo G, Demirov D, Goffinet AM.
Genomic organization of the mouse reelin gene. Genomics. 1997 Dec 1;46(2):240-50.
PubMed PMID: 9417911.
de Bergeyck V, Nakajima K, Lambert de Rouvroit C, Naerhuyzen B, Goffinet AM,
Miyata T, Ogawa M, Mikoshiba K. A truncated Reelin protein is produced but not
secreted in the 'Orleans' reeler mutation (Reln[rl-Orl]). Brain Res Mol Brain
Res. 1997 Oct 15;50(1-2):85-90. PubMed PMID: 9406921.
Goffinet AM. Developmental neurobiology. Unscrambling a disabled brain.
Nature. 1997 Oct 16;389(6652):668-9. PubMed PMID: 9338772.
Resibois A, Cuvelier L, Goffinet AM. Abnormalities in the cerebellum and
brainstem in homozygous lurcher mice. Neuroscience. 1997 Sep;80(1):175-90. PubMed
PMID: 9252230.
Ware ML, Fox JW, González JL, Davis NM, Lambert de Rouvroit C, Russo CJ, Chua
SC Jr, Goffinet AM, Walsh CA. Aberrant splicing of a mouse disabled homolog,
mdab1, in the scrambler mouse. Neuron. 1997 Aug;19(2):239-49. PubMed PMID:
9292716.
Royaux I, Bernier B, Montgomery JC, Flaherty L, Goffinet AM. Reln(rl-Alb2),
an allele of reeler isolated from a chlorambucil screen, is due to an IAP
insertion with exon skipping. Genomics. 1997 Jun 15;42(3):479-82. PubMed PMID:
9205121.
Schiffmann SN, Bernier B, Goffinet AM. Reelin mRNA expression during mouse
brain development. Eur J Neurosci. 1997 May;9(5):1055-71. PubMed PMID: 9182958.
Goffinet AM. Developmental neurobiology. A real gene for reeler. Nature. 1995
Apr 20;374(6524):675-6. PubMed PMID: 7715721.
Bar I, Lambert De Rouvroit C, Royaux I, Krizman DB, Dernoncourt C, Ruelle D,
Beckers MC, Goffinet AM. A YAC contig containing the reeler locus with
preliminary characterization of candidate gene fragments. Genomics. 1995 Apr
10;26(3):543-9. PubMed PMID: 7607678.
Beckers MC, Bar I, Huynh-Thu T, Dernoncourt C, Brunialti AL, Montagutelli X,
Guénet JL, Goffinet AM. A high-resolution genetic map of mouse chromosome 5
encompassing the reeler (rl) locus. Genomics. 1994 Oct;23(3):685-90. PubMed PMID:
7851897.
Gadisseux JF, Goffinet AM, Lyon G, Evrard P. The human transient subpial
granular layer: an optical, immunohistochemical, and ultrastructural analysis. J
Comp Neurol. 1992 Oct 1;324(1):94-114. PubMed PMID: 1401263.
Goffinet AM. The reeler gene: a clue to brain development and evolution. Int
J Dev Biol. 1992 Mar;36(1):101-7. PubMed PMID: 1627461.
Dernoncourt C, Ruelle D, Goffinet AM. Estimation of genetic distances between
"reeler" and nearby loci on mouse chromosome 5. Genomics. 1991 Dec;11(4):1167-9.
PubMed PMID: 1783386.
Goffinet AM, Dernoncourt C. Localization of the reeler gene relative to
flanking loci on mouse chromosome 5. Mamm Genome. 1991;1(2):100-3. PubMed PMID:
1686837.
De Volder AG, Cirelli S, de Barsy T, Brucher JM, Bol A, Michel C, Goffinet
AM. Neuronal ceroid-lipofuscinosis: preferential metabolic alterations in
thalamus and posterior association cortex demonstrated by PET. J Neurol Neurosurg
Psychiatry. 1990 Dec;53(12):1063-7. PubMed PMID: 2292699; PubMed Central PMCID:
PMC488316.
Goffinet AM. Cerebellar phenotype of two alleles of the 'reeler' mutation on
similar backgrounds. Brain Res. 1990 Jun 11;519(1-2):355-7. PubMed PMID: 1697778.
Goffinet AM, De Volder AG, Bol A, Michel C. Brain glucose utilization under
high sensory activation: hypoactivation of prefrontal cortex. Aviat Space Environ
Med. 1990 Apr;61(4):338-42. PubMed PMID: 2339969.
Veraart C, De Volder AG, Wanet-Defalque MC, Bol A, Michel C, Goffinet AM.
Glucose utilization in human visual cortex is abnormally elevated in blindness of
early onset but decreased in blindness of late onset. Brain Res. 1990 Feb
26;510(1):115-21. PubMed PMID: 2322834.
DeVolder AG, Goffinet AM, Bol A, Michel C, de Barsy T, Laterre C. Brain
glucose metabolism in postanoxic syndrome. Positron emission tomographic study.
Arch Neurol. 1990 Feb;47(2):197-204. PubMed PMID: 2302091.
Goffinet AM. Determinants of nerve cell patterns during development: a
review. Eur J Morphol. 1990;28(2-4):149-68. Review. PubMed PMID: 2245131.
Goffinet AM, Leysen J, Labar D. In vitro pharmacological profile of
3-N-(2-fluoroethyl)spiperone. J Cereb Blood Flow Metab. 1990 Jan;10(1):140-2.
PubMed PMID: 2137131.
Bol A, Vanmelckenbeke P, Michel C, Cogneau M, Goffinet AM. Measurement of
cerebral blood flow with a bolus of oxygen-15-labelled water: comparison of
dynamic and integral methods. Eur J Nucl Med. 1990;17(5):234-41. PubMed PMID:
2083558.
De Volder AG, Francart J, Laterre C, Dooms G, Bol A, Michel C, Goffinet AM.
Decreased glucose utilization in the striatum and frontal lobe in probable
striatonigral degeneration. Ann Neurol. 1989 Aug;26(2):239-47. PubMed PMID:
2789014.
Goffinet AM, Nguyen A. Brain leukotriene C4 binding sites are
S-alkylglutathione binding sites. Eur J Pharmacol. 1989 Feb 14;161(1):99-101.
PubMed PMID: 2542040.
Goffinet AM, De Volder AG, Gillain C, Rectem D, Bol A, Michel C, Cogneau M,
Labar D, Laterre C. Positron tomography demonstrates frontal lobe hypometabolism
in progressive supranuclear palsy. Ann Neurol. 1989 Feb;25(2):131-9. PubMed PMID:
2784043.
Michel C, Bol A, De Volder AG, Goffinet AM. Online brain attenuation
correction in PET: towards a fully automated data handling in a clinical
environment. Eur J Nucl Med. 1989;15(11):712-8. PubMed PMID: 2583198.
De Volder A, Ghilain S, de Barsy T, Goffinet AM. Brain metabolism in
mitochondrial encephalomyopathy: a PET study. J Comput Assist Tomogr. 1988
Sep-Oct;12(5):854-7. PubMed PMID: 3262636.
De Volder AG, Jaeken J, Van den Berghe G, Bol A, Michel C, Cogneau M,
Goffinet AM. Regional brain glucose utilization in adenylosuccinase-deficient
patients measured by positron emission tomography. Pediatr Res. 1988
Aug;24(2):238-42. Erratum in: Pediatr Res 1989 Feb;25(2):118. PubMed PMID:
3263613.
De Volder A, Sindic CJ, Goffinet AM. Effect of D-penicillamine treatment on
brain metabolism in Wilson's disease: a case study. J Neurol Neurosurg
Psychiatry. 1988 Jul;51(7):947-9. PubMed PMID: 3264567; PubMed Central PMCID:
PMC1033199.
Godfraind C, Schachner M, Goffinet AM. Immunohistological localization of
cell adhesion molecules L1, J1, N-CAM and their common carbohydrate L2 in the
embryonic cortex of normal and reeler mice. Brain Res. 1988 Jul 1;470(1):99-111.
PubMed PMID: 2457413.
De Volder AG, Bol A, Michel C, Cogneau M, Goffinet AM. [Cerebral glucose
metabolism in autistic children. Study and positron emission tomography]. Acta
Neurol Belg. 1988 Mar-Apr;88(2):75-90. French. PubMed PMID: 3260437.
Laterre EC, De Volder AG, Goffinet AM. Brain glucose metabolism in thalamic
syndrome. J Neurol Neurosurg Psychiatry. 1988 Mar;51(3):427-8. PubMed PMID:
3258903; PubMed Central PMCID: PMC1032873.
De Volder A, Bol A, Michel C, Cogneau M, Evrard P, Lyon G, Goffinet AM.
Brain glucose utilization in childhood Huntington's disease studied with positron
emission tomography (PET). Brain Dev. 1988;10(1):47-50. PubMed PMID: 2967038.
De Volder A, Bol A, Michel C, Congneau M, Goffinet AM. Brain glucose
metabolism in children with the autistic syndrome: positron tomography analysis.
Brain Dev. 1987;9(6):581-7. PubMed PMID: 3502233.
Goffinet AM, Caviness VS Jr. Autoradiographic localization of beta 1 and
alpha 1-adrenoceptors in the midbrain and forebrain of normal and reeler mutant
mice. Brain Res. 1986 Feb 26;366(1-2):193-202. PubMed PMID: 3008909.
Goffinet AM, Daumerie C, Langerwerf B, Pieau C. Neurogenesis in reptilian
cortical structures: 3H-thymidine autoradiographic analysis. J Comp Neurol. 1986
Jan 1;243(1):106-16. PubMed PMID: 3950076.
Goffinet AM. [Leukotriene C4 binding sites in the mouse forebrain:
autoradiographic demonstration]. C R Acad Sci III. 1986;302(17):633-6. French.
PubMed PMID: 3019488.
Goffinet AM, Hemmendinger LM, Caviness VS Jr. Autoradiographic study of beta
1-adrenergic receptor development in the mouse forebrain. Brain Res. 1986
Jan;389(1-2):187-91. PubMed PMID: 3004667.
Goffinet AM, De Volder A. Autoradiographic analysis of adrenergic receptors
in the mammalian brain. Acta Neurol Belg. 1985 Mar-Apr;85(2):82-109. PubMed PMID:
2988261.
Goffinet AM, So KF, Yamamoto M, Edwards M, Caviness VS Jr. Architectonic and
hodological organization of the cerebellum in reeler mutant mice. Brain Res. 1984
Nov;318(2):263-76. PubMed PMID: 6498501.
Goffinet AM. Events governing organization of postmigratory neurons: studies
on brain development in normal and reeler mice. Brain Res. 1984
Aug;319(3):261-96. Review. PubMed PMID: 6383524.
Goffinet AM. Abnormal development of the facial nerve nucleus in reeler
mutant mice. J Anat. 1984 Mar;138 ( Pt 2):207-15. PubMed PMID: 6715246; PubMed
Central PMCID: PMC1164061.
Goffinet AM. Phylogenetic determinants of radial organization in the
cerebral cortex. Z Mikrosk Anat Forsch. 1984;98(6):909-25. Review. PubMed PMID:
6396995.
Goffinet AM. The embryonic development of the inferior olivary complex in
normal and reeler (rlORL) mutant mice. J Comp Neurol. 1983 Sep 1;219(1):10-24.
PubMed PMID: 6619327.
Goffinet AM. The embryonic development of the cortical plate in reptiles: a
comparative study in Emys orbicularis and Lacerta agilis. J Comp Neurol. 1983 Apr
20;215(4):437-52. PubMed PMID: 6863592.
Goffinet AM. The embryonic development of the cerebellum in normal and
reeler mutant mice. Anat Embryol (Berl). 1983;168(1):73-86. PubMed PMID: 6650858.
Della Giustina E, Goffinet AM, Landrieu P, Lyon G. A Golgi study of the
brain malformation in Zellweger's cerebro-hepato-renal disease. Acta Neuropathol.
1981;55(1):23-8. PubMed PMID: 7348002.
Goffinet AM. The cerebral cortex of the reeler mouse embryo. An electron
microscopic analysis. Anat Embryol (Berl). 1980;159(2):199-210. PubMed PMID:
7447037.
Goffinet AM. An early development defect in the cerebral cortex of the
reeler mouse. A morphological study leading to a hypothesis concerning the action
of the mutant gene. Anat Embryol (Berl). 1979 Oct;157(2):205-16. PubMed PMID:
517767.
Goffinet AM, Lyon G. Early histogenesis in the mouse cerebral cortex: a
Golgi study. Neurosci Lett. 1979 Sep;14(1):61-6. PubMed PMID: 530488.
Goffinet AM, Laterre C. [Tick-bite meningoradiculitis (author's transl)].
Acta Neurol Belg. 1978 Jul-Aug;78(4):217-22. French. PubMed PMID: 685662.
